Oral miltefosine for refractory Acanthamoeba keratitis
نویسندگان
چکیده
منابع مشابه
[Acanthamoeba keratitis].
Three patients, women aged 69, 25 and 30 years, with refractory keratitis were found to have a rare infection with Acanthamoeba. All wore soft contact lenses. The frequency of Acanthamoeba keratitis increased in recent years. At present, an efficacious antiprotozoal therapy is available, for instance in the form of polyhexamethylene biguanide and propamidine. In cases of refractory keratitis, t...
متن کاملPersistence of acanthamoeba antigen following acanthamoeba keratitis.
AIM To investigate the hypothesis that persistent corneal and scleral inflammation following acanthamoeba keratitis is not always caused by active amoebic infection but can be due to persisting acanthamoebic antigens METHODS 24 lamellar corneal biopsy and penetrating keratoplasty specimens were obtained from 14 consecutive patients at various stages of their disease and divided for microscopy...
متن کاملAcanthamoeba endophthalmitis following penetrating keratoplasty for Acanthamoeba keratitis.
membrane bilaterally. Fundus examination revealed no pigmentation. Dental, oral mucosal, skin, and nail pigmentation were evident (Figure 1F). The diagnosis of argyrosis was confirmed by conjunctival biopsy. It was possibly due to occupational inhalation of silver. The Scheimpflug image displayed hyperreflectivity corresponding to corneal pigment accumulation areas at the superficial layers (Fi...
متن کاملDouble-Biguanide Therapy for Resistant Acanthamoeba Keratitis
AIMS To report the clinical and diagnostic findings of a patient with Acanthamoeba keratitis resistant to both polyhexamethylene biguanide (PHMB)-hexamidine and chlorhexidine-hexamidine treatment. METHODS Slit-lamp biomicroscopy, corneal cell scraping and histopathology were performed on a 39-year-old woman presenting with corneal ulcer in her left eye. RESULTS The patient was successfully ...
متن کاملAcanthamoeba keratitis successfully treated medically.
The first medical cure of a corneal infection due to an Acanthamoeba species is reported. The 44-year-old patient developed a suppurative keratitis associated with an epithelial defect, hypopyon, and secondary glaucoma. Acanthamoeba was confirmed as the causative agent four months after presentation when positive cultures were obtained from the cornea and from the conjunctiva. Sensitivity studi...
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ژورنال
عنوان ژورنال: American Journal of Ophthalmology Case Reports
سال: 2019
ISSN: 2451-9936
DOI: 10.1016/j.ajoc.2019.100555